A New Generation Approach to Fighting Mosquitoes: Efficacy and Safety of Hybrid Insecticide Formulation with Synthetic and Natural Components

Abstract

Mosquitoes are among the major vector organisms that threaten human health and play an important role in the spread of many infectious diseases such as malaria, dengue, Zika and chikungunya. The widespread and long-term use of conventional insecticides has harmful effects on both the environment and non-target organisms, and also accelerates the development of resistance in vector populations. This study introduces a hybrid insecticide formulation containing synthetic (deltamethrin, pyriproxyfen, PBO) and natural (azadirachtin, thymol, eugenol, mushroom extract) components, designed to be highly effective against adult and larval mosquito forms. This formulation, which uses microcapsule and suspension concentrate technologies together, offers a synergistic structure in suppressing the vector population with multiple mechanisms of action at neurotoxic, hormonal and behavioral levels. In addition, the environmentally friendly properties of the components, low toxicity profile and biodegradability levels increase the safety of the formulation in terms of human health and the ecosystem. The study evaluates the applicability of this hybrid structure in integrated vector control programs and indicates that it can be further developed with nanotechnological carrier systems in the future.